Preclinical evaluation of antimetastatic drug candidates using a next-generation chicken embryo model

Despite intensive research to identify therapeutic targets and develop new antimetastatic drugs, it still remains the leading cause of cancer patient .. Read more death. This is mainly because metastasis is a dynamic process, which is complex to model. Actual preclinical models are very often built for anti-proliferative drug development and do not recapitulate all steps in the metastatic process. Moreover, the biology of metastatic cells differs completely from primary tumor cells. It is therefore necessary to rethink existing preclinical models and determine new endpoints that properly evaluate their antimetastatic properties in designing new drugs to prevent or delay metastatis. The chicken embryo model presents the advantage of recapitulating all steps of spontaneous metastasis in 9 days including the formation of a primary tumor, intravasation, extravasation from the vasculature and establishment at distant sites. Throughout her career, Chloé has acquired expertise in preclinical models applied to cancer research and in vivo imaging to study cancer progression.