Although pharmacological intervention is the current gold standard treatment for many neurodegenerative and neuropsychiatric disorders, they carry .. Read more many unwanted side effects. Non-pharmacological alternatives such as electrical stimulation – used mostly as an adjunct therapy – has gained recent interest. Vagus nerve stimulation (VNS) is a neuromodulation technique that impacts multiple neurotransmitter systems. VNS involves an invasive surgical implantation of a generator subcutaneously providing direct electrical stimulation of the cervical vagus nerve. VNS is currently an approved adjunct treatment for drug-resistant epilepsy and in patients with treatment-resistant depression. However, the effects VNS exerts may also be beneficial for other neurological disorders. Recently, non-invasive VNS devices have been developed with the aim of stimulating the vagus nerve transcutaneously, significantly reducing the risk associated with the implantable device.
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