15 Sep 2021 • 

Continuous Manufacturing of Biologics: A Journey from Concept to Reality


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Sep 2021


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Enzene Biosciences has been one of the early movers in development of continuous manufacturing platforms for the production of Biologics. The company .. Read more has developed multiple products using their continuous manufacturing platform which are now being tested in clinical studies. This talk encapsulates the learnings in developing this platform from early stages of development to scale-up and GMP manufacturing. Key areas include challenges specific to continuous manufacturing such as process optimization, process characterization, automation, in-line process analytics with emphasis on the considerations towards design of the manufacturing plant. Additionally, elucidation of emerging opportunities with respect to lean manufacturing, increased volumetric productivity, reduction of manufacturing footprint and its resulting impact on lower COGs will also be discussed along with a case study on factors for conversion of fed-batch process to a perfusion process. Concluding the talk with a precis of the crucial drivers which are leading to the emergence of continuous manufacturing as the preferred manufacturing platform for Biologics production.

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