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15 Mar 2024

CTPR SEMINAR SERIES: with Dr. Tomas Nevian

Conference
Chicago, USA

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The perception of pain is a multidimensional sensory and emotional/affective experience arising from distributed brain activity. However, the involved brain regions are not specific for pain. Thus, how the cortex distinguishes nociception from other aversive and salient sensory stimuli remains elusive. Additionally, the consequences of the plastic changes that induce chronic neuropathic pain on sensory processing have not been characterized properly. Using in vivo miniscope calcium imaging with .. continue reading cellular resolution in freely moving mice, we studied the principles of nociceptive and sensory coding in the anterior cingulate cortex (ACC), a region essential for pain processing. We found that population activity, not single-cell responses, allowed discriminating noxious from other sensory stimuli, ruling out the existence of nociception-specific neurons. Additionally, single-cell stimulus selectivity was highly dynamic over time, but stimulus representation at the population level remained stable. Peripheral nerve injury-induced chronic neuropathic pain led to dysfunctional encoding of sensory events by exacerbation of responses to innocuous stimuli and impairment of pattern separation and stimulus classification, which were restored by analgesic treatment. Furthermore, I will discuss the influence of afferent pathways to the ACC that contribute to nociceptive processing and behavioral decision-making in pain.

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Timings

01:00 PM - 02:00 PM General Hours

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Estimated Turnout

upto 100
Delegates
Based on previous editions

Event Type

Conference

Editions

Mar 2024
+1 more edition

Frequency Bi-annual
Next edition likely in Sep 2024

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Different Located Editions
Harrisburg, USA24 Aug 2023

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Northwestern University

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Chicago, USA

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