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14 Oct 2020Ended

Reduced Vitamin K Status as a Potentially Modifiable Prognostic Risk Factor in Covid-19

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14 Oct 2020

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Reduced Vitamin K Status as a Potentially Modifiable Prognostic Risk Factor in Covid-19 will present results from our recent study on vitamin K .. Read more status in SARS-CoV-2 patients. We found severely impaired vitamin K-dependent activation of matrix-Gla-protein (MGP), strongly correlated with increased elastic fiber degradation (as measured by levels of plasma desmosine with LC-MS/MS). Our data suggest a mechanism of pneumonia-induced extrahepatic vitamin K depletion leading to accelerated elastic fiber damage in severe COVID-19 due to impaired activation of MGP. The talk includes a detailed description of the role of vitamin K in hepatic as well as extrahepatic metabolism and its inter-relationship with elastin calcification and elastin degradation as pathological processes that impair elastin’s functioning. Also, details of our LC-MS/MS assay for measurement of desmosine in body fluids will be presented.

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