19 - 20 May 2021

Protein-Protein Interactions



09:00 AM - 06:00 PM
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upto 100
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May 2021
+1 more edition


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More examples in medical research are now arising about diseases that can be addressed by disrupting or modifying complexes of proteins that .. Read more aberrantly interact with one another. Such protein-protein interaction (PPI) complexes can be considered a type of drug target. PPI targets are different from traditional drug targets that comprise of a single protein, more specifically an enzyme, whose function is targeted for reduction by a chemical inhibitor. For the medicinal chemist whose role is to discover, design or optimize compounds with therapeutic potential, PPIs are expanding what can be ‘drugged or targeted’ by them. However, the ‘flat and large’ interacting surfaces of PPIs make them less amenable to the typical ‘groove and ball’ inhibitor design strategy for enzymes. Luckily, advances in biophysical techniques such as nuclear magnetic resonance (NMR), surface plasmon resonance (SPR) that enable rapid detection of bi-molecular interactions without an enzymatic readout, have aided progress in finding new drug leads against PPIs. At CHI’s 13th Annual Protein-Protein Interactions conference, join fellow discovery chemists to share stories and discuss best practices in this new area of disease-relevant space that is rapidly becoming more accessible.

2   Different Located Editions
San Diego, USA26 - 27 Aug 2020
Boston, USA08 - 09 Oct 2014
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