10times
28 - 29 Sep 2021Ended

PROTACs and Targeted Protein Degradation

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Timings

09:00 AM - 06:00 PM
Not Verified

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Estimated Turnout

upto 100
Delegates
Based on previous editions

Editions

Sep 2021
+1 more edition

Frequency

Annual
Next edition likely in Sep 2022
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PROTACs and Targeted Protein Degradation conference will discuss ways to design and optimize small molecule degraders such as, proteolysis-targeting .. Read more chimeras (PROTACs), E3 ligase and deubiquitinating enzyme (DUB) modulators, thalidomides and other molecular glues. They consist of well-controlled, selective mechanisms for intracellular protein degradation, however, the diversity and complexity makes it difficult to target these pathways for therapeutic intervention. Better understanding of ways to modulate these pathways using chemical probes, small molecule ligands and innovative screening platforms have made some UPS and autophagy targets more "druggable". Cambridge Healthtech Institute’s conference on PROTACs and Targeted Protein Degradation will bring together chemists, biologists and pharmacologists to discuss the progress that has been made and the challenges that are yet to be overcome. The first part of the PROTACs and Targeted Protein Degradation conference will discuss ways to design and optimize small molecule degraders such as, proteolysis-targeting chimeras (PROTACs), E3 ligase and deubiquitinating enzyme (DUB) modulators, thalidomides and other molecular glues. The UPS and autophagy pathways hold a lot of promise in seeking out previously “undruggable” targets for therapeutic intervention. The second part of the PROTACs and Targeted Protein Degradation conference will focus on emerging assays and screening strategies for identifying ligases, chaperone proteins, DUBs and other proteins that can be modulated for targeted protein degradation.

1   Different Located Editions
Boston, USA28 - 29 Sep 2021
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