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05 Nov 2020Ended

Rodents and Rabbits The Traditional DART Models

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05 Nov 2020

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Join us for part three of our four-part DART series, where we’ll talk about the two most common models for developmental and reproductive toxicity .. Read more testing. First, we’ll examine why the rat is well liked by researchers when studying in vivo DART testing. We’ll also take a look at the three most commonly used study designs – fertility and early embryonic development, embryo-fetal developmental toxicity (EFD), and pre/postnatal development – along with some infrequently used ones. You’ll learn about the aspects of study design, exposure assessment, dose selection and timing, and the advantages and drawbacks of including optional endpoints included in ICH S5. Then, we will look at the most commonly used second species for EFD toxicity studies – the rabbit. See why they are the preferred model to studying vaccine candidates and why you should consider them for any study involving small or large molecules, or medical device testing. You’ll also learn how to determine exposure and tolerability, appropriate timing and conduct of dose-range studies for EFD toxicity studies, and study designs.

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Charles River

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