High Throughput Screening, Synthesis and Enzymatic Assay System: Clinical Relevance will describe an automated high throughput screening system which .. Read more is used to acquire mass spectra at using desorption electrospray ionization (DESI). The system has been used to screen organic reactions and select optimum conditions for scaled-up drug synthesis, to analyze biological fluids without sample workup, to examine tissue library arrays and to perform label-free quantitative measurements of enzyme kinetics. Extensions of the instrumentation to collection of small amounts of synthesis products for in situ bioassays are also described.
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