22 Jun 2021Ended

FOX Three Molecular Guidance System: A Novel Platform for Targeted Intracellular Delivery of Biotherapeutics


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upto 100
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Jun 2021


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There is an overwhelming need for systematic cell-targeting systems that deliver bioactive cargo to a specific cell type and to precise locations .. Read more within that cell. Identified MGSs home onto desired cell types and deliver payloads to discrete subcellular locations within those cells. FOX Three utilizes highly diverse, phage-displayed peptide libraries to rapidly identify MGSs. Furthermore, we have demonstrated that MGSs can deliver virtually any cargo inside the target cells, regardless of size or composition. We have identified greater than 40 MGSs that target differing cell types ranging from cancer to cardiomyocytes. MGSs home to their target cell type in vivo and redirect biotherapeutics to the desired tissues. They advanced the platform to identify delivery systems that exhibit both cellular and subcellular specificity, allowing for precision delivery previously unobtainable.

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