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04 May 2021 • 

Transcriptome-Guided Analysis of Highly Multiplexed Immunohistochemistry Images

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May 2021

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Recently developed technologies for digital imaging and highly multiplexed immunohistochemistry (mIHC) advancing the field of histology into a .. Read more quantitative era, allowing for more complex descriptions of tissue architecture. Imaging cytometry by time of flight (CyTOF), multiplexed ion beam imaging, and co-detection by indexing (CODEX) can be used to simultaneously profile the expression of dozens of proteins in a tissue section with single-cell resolution. However, annotating cell populations or states that differ little in the profiled antigens or for which the antibody panel does not include specific markers is challenging. This webinar will present a computational approach that was developed to overcome this obstacle. Spatially resolved Transcriptomics via Epitope Anchoring (STvEA) enriches mIHC images with single-cell RNA-seq data, building upon recent experimental procedures for augmenting single-cell transcriptomes with concurrent antigen measurements such as CITE-seq (Cellular Indexing of Transcriptomes and Epitopes by Sequencing).

Daniel WAFO FOSSO

Daniel WAFO FOSSO

StudentResearcher at University of Douala

Kwamba, Nigeria
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