4.3 /5

Small G Proteins

29 - 30 Sep 2021Add To Calendar
Sheraton Boston Hotel, Boston, USA
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KRAS and other members of the Ras family of small G proteins have been known for years to be highly associated, in their mutated forms, with a variety of cancers, thereby establishing Ras proteins as controllers of cellular growth. But only recently have RAS-targeted drug candidates, specifically against KRAS, entered clinical trials thanks to innovative medicinal chemistry and biophysical approaches. Small G proteins lack structural features in their enzymatic GPTase domain typically required for binding of small molecule inhibitors. With KRAS progress cracking open the field, drug discovery attention has also turned to other types of Ras proteins and even other small G proteins such as Rho and Rab that play structural or other signaling roles in the cell.


09:00 AM-06:00 PM (expected)
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Medical & Pharma


Sep 2021 Interested

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